Ready to get a patient started on AURYXIA?

Learn about dosing and titration.

AURYXIA is uniquely formulated for your patients:

  • An iron-based, non-calcium tablet1
  • Film-coated tablet that is swallowed, not chewed or crushed1
  • No discoloration of the mouth when swallowed whole1

Dosing guidelines1

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AURYXIA is taken
with meals

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Starting dose 2 tablets
3 times/day

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Adjust dose every week (or longer) as needed

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Maximum dose
12 tablets daily

Titration guidelines

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AURYXIA can be titrated in increments or decrements of 1 to 2 tablets per day to maintain serum phosphorus target levels1

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Titrate AURYXIA at 1-week or longer intervals1

Oral drugs that cannot be taken at the same time as AURYXIA1

  • Doxycycline—Take at least 1 hour before AURYXIA
  • Ciprofloxacin—Take at least 2 hours before or after AURYXIA
  • For oral medications where a reduction in bioavailability would have a clinically significant effect, consider separation of timing of administration with AURYXIA



AURYXIA® (ferric citrate) is contraindicated in patients with iron overload syndromes, e.g., hemochromatosis


  • Iron Overload: Increases in serum ferritin and transferrin saturation (TSAT) were observed in clinical trials with AURYXIA in patients with chronic kidney disease (CKD) on dialysis treated for hyperphosphatemia, which may lead to excessive elevations in iron stores. Assess iron parameters prior to initiating AURYXIA and monitor while on therapy. Patients receiving concomitant intravenous (IV) iron may require a reduction in dose or discontinuation of IV iron therapy
  • Risk of Overdosage in Children Due to Accidental Ingestion: Accidental ingestion and resulting overdose of iron-containing products is a leading cause of fatal poisoning in children under 6 years of age. Advise patients of the risks to children and to keep AURYXIA out of the reach of children


The most common adverse reactions reported with AURYXIA in clinical trials were:

  • Diarrhea (21%), discolored feces (19%), nausea (11%), constipation (8%), vomiting (7%) and cough (6%)


  • Pregnancy and Lactation: There are no available data on AURYXIA use in pregnant women to inform a drug-associated risk of major birth defects and miscarriage. However, an overdose of iron in pregnant women may carry a risk for spontaneous abortion, gestational diabetes and fetal malformation. Data from rat studies have shown the transfer of iron into milk, hence, there is a possibility of infant exposure when AURYXIA is administered to a nursing woman


When clinically significant drug interactions are expected, e.g., Ciprofloxacin or Doxycycline, separate timing of administration.


AURYXIA® (ferric citrate) is indicated for the control of serum phosphorus levels in adult patients with chronic kidney disease on dialysis

To report suspected adverse reactions, contact Akebia Therapeutics, Inc. at 1-844-445-3799

Please see full Prescribing Information


  1. AURYXIA® [Package Insert]. Cambridge, MA: Akebia Therapeutics, Inc.